Student Research Positions (Laboratory & Computational Biophysics of Ion Channels)
Two types of Research/Degree Projects are currently available in the Science for Life Laboratory group headed by Professor Erik Lindahl. Under the supervision of Dr Reba Howard, students in this interdisciplinary group will focus on laboratory or computational biophysics approaches to investigate the structure and function of proteins involved in neurological signalling, particularly the activation and modulation of ion channels.
Project 1—Electrophysiology of Novel Receptor Variants
Express and characterize ion channel proteins in a model cell system, using molecular biology and voltage-clamp recordings to quantify expression, gating, and modulation
towards structure determination and/or drug development.
Project 2—Simulating Receptor Gating and Modulation
Harness recent high-resolution structure-function data to build, simulate, and analyze model ion channel models, using molecular dynamics to probe and engineer structural
changes, drug binding pockets, and/or novel mutations.
Further details
Applicants should have some theoretical and/or laboratory preparation in biophysics, biochemistry, or related fields at the Bachelor’s or Master’s levels, and an enthusiasm for
interdisciplinary research and communication. For inquiries or further details, contact rebecca.howard@scilifelab.se.
Last updated: March 16, 2022
Source: Department of Biochemistry and Biophysics