Group Spetz published in Advanced Science

Group Spetz has recently published the article "A Non-Coding Oligonucleotide Recruits Cutaneous CD11b+ Cells that Inhibit Thelper Responses and Promote Tregs" in Advanced Science.

Kamal et.al. elucidated the immunoregulatory role of an oligonucleotide (ssON) that was found to recruit cutaneous immunoregulatory antigen-presenting cells (APCs) with increased immune checkpoint protein expression. Functional T-cell assays revealed that such immunoregulatory APCs inhibited T-helper cell responses and promoted CD4+FoxP3+Tregs. This study envisions the use of ssON as therapeutic for rebalancing overactive T-helper cell responses in the skin.

Created in: Biorender

To read the full article and to read more about Anna-Lena Spetz research group and reserach, follow the links below:

Full article: https://onlinelibrary.wiley.com/doi/10.1002/advs.202400260

English: Group Spetz

Swedish: Group Spetz

Research subject

Infection and Immunobiology

Research project

Exploring the role of a non-coding oligonucleotide to dampen skin inflammation and itch

Research group

Group Spetz

We are exploring basic mechanisms regarding a group of small non-coding oligonucleotides and their therapeutic potential. We have discovered that a set of single-stranded oligonucleotides temporarily inhibit certain endocytic pathways and thereby modulate innate immune responses as well as providing anti-viral effects.

Last updated: July 1, 2024

Source: MBW