• Lärarassistent för analytisk kemi grundkurs VT24

• Postdoktor Marie Skłodowska-Curie Actions-projektet "DVD-läsbar opto-elektrokemisk Lab-on-a-Disc som bärbar trådlös medicinsk enhet med liten faktor för fetmahantering". En ny kostnadseffektiv och bärbar multiplexerad medicinsk enhet, med unika och aldrig tidigare skådade egenskaper, för exakt hantering av kroniska sjukdomar.
• Projektet "In situ miljöövervakning med en pappersrulle". Målet med projektet är att utveckla ett "papperstryckt laboratorium", genom att integrera optisk och elektrokemisk avkänning på en pappersmikrofluidikplattform. Det kommer att göra det möjligt att samla in kemiska och biologiska data till låg kostnad och att upptäcka föroreningar och viktiga miljöparametrar vid högre frekvenser och högre rumslig täthet, vilket resulterar i en robust och kostnadseffektiv teknik för en bättre förvaltning av vattenmiljön.

I urval från Stockholms universitets publikationsdatabas

• Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues

  2023. Antonio Velarte (et al.). Biosensors 13 (10)

  Artikel

  Cardiovascular diseases cause a high number of deaths nowadays. To improve these statistics, new strategies to better understand the electrical and mechanical abnormalities underlying them are urgently required. This study focuses on the development of a sensor to measure tissue stretch in excised tissues, enabling improved knowledge of biomechanical properties and allowing greater control in real time. A system made of biocompatible materials is described, which is based on two cantilevered platforms that integrate an optical fiber inside them to quantify the amount of stretch the tissues are exposed to with a precision of mu m. The operating principle of the sensor is based on the variation of the optical path with the movement of the platforms onto which the samples are fixed. The conducted tests highlight that this system, based on a simple topology and technology, is capable of achieving the desired purpose (a resolution of similar to 1 mu m), enabling the tissue to be bathed in any medium within the system.

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• A novel integrated platform enabling simultaneous microextraction and chemical analysis on-chip

  2023. Elia Santigosa-Murillo (et al.). Microchemical journal (Print) 193, 109044-109044

  Artikel

  The nature and size of biological, pharmaceutical or environmental analytes complicates their extraction and detection outside of laboratories and near the site of interest by the current chromatographic methods because they require the combination of bulky extraction and detection methods. In order to solve this inefficient centralized control, a ground-breaking and miniaturized proof of concept platform is developed in this work. The platform integrates for the very first time an electro-membrane extraction process and an accurate analyte quantification method in the same device, by using electrochemical impedance spectroscopy (EIS) as analytical technique. The microfluidic flow cell, including the microfluidic components, is fabricated in polymeric materials by rapid prototyping techniques. It comprises a four-electrode platinum thin-film chip that enables the control of the microextraction and the full characterization of the process, i.e., extraction efficiency determination, at the same time. The microfluidic system has been simulated by using computational tools, enabling an accurate prediction of the effect of the different experimental conditions in the microextraction efficiency. The platform has been validated in the microextraction of the nonsteroidal anti-inflammatory drug ketoprofen in a range from 0.5 ppm to 6 ppm. The predicted microextraction efficiency values obtained by EIS were compared with those calculated from the high-performance liquid chromatography coupled with a diode array detector (HPLC-DAD), showing an excellent agreement. This validates the high potential of this integrated and miniaturized platform for the simultaneous extraction by electro-membrane and also the analysis within the platform, solving one of the of most important limitations of current systems.

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• Distance-based paper analytical device for the determination of dissolved inorganic carbon concentration in freshwater

  2023. Pablo Giménez-Gómez (et al.). Sensors and actuators. B, Chemical 385, 133694-133694

  Artikel

  Dissolved inorganic carbon (DIC) levels in freshwaters play a key role in the equilibrium of the carbon cycle between the atmosphere, water and living beings. Standard classical methods for DIC determination generally involve bulky and expensive equipment used in centralized laboratories, resulting in time-consuming processes that do not allow for adequate monitoring in the field. In order to address this challenge, we have developed a distance-based paper analytical device (PAD) for on-site determination of DIC in water. The portable, cost-effective and easy-to-use device was based on the miniaturization and integration of a classical acid-base colorimetric titration on a paper channel, enabling an accurate determination of DIC in less than 20 min. The length of the blue colored line in the detection channel after being filled with the sample was related to the DIC concentration in the sample. The reagent solution used to modify the titration channel was optimized so that DIC concentrations in the range 50–1000 mg L−1 could be measured. The long-term stability of the paper-based device was also evaluated, demonstrating a working stability for more than 70 days after their fabrication, an important characteristic for in-the-field analysis. Finally, the PAD was validated with different water samples, i.e. tap water, commercial bottled drinking water and water samples from a mine, with excellent agreement between the results obtained from the PAD and the standard method. This demonstrates the high potential of the proposed paper analytical device to quantify DIC in situ by minimally-trained personnel without the need for peripheral equipment, which represents an important advance compared to the current limited analysis systems.

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