Research group Anneli Kruve group
We use modelling and machine learning to understand ionization processes in electrospray (ESI) and developing semi-quantitative non-targeted analysis methodology.
![Kruve lab](/polopoly_fs/1.673801.1694523673!/image/image.jpg_gen/derivatives/widescreen_690/image.jpg)
Group description
Quantification is crucial in all branches of analytical chemistry: environmental analysis, metabolomics, and monitoring food contaminants. The method of choice often is mass spectrometry, which guarantees low detection limits and high selectivity. However, targeted analysis is often tedious and limited in their coverage as standards are needed to evaluate the vast differences in ionization efficiencies of different compounds in the electrospray ionization source.
The non-targeted analysis with mass spectrometry has been developed to allow detection of contaminants, metabolites, etc. without the use of standard compounds. Still, the lack of quantitative information remains one of the major bottlenecks in non-targeted metabolomics. We develop novel strategies for non-targeted quantification using conventional LC-MS and machine learning approaches.
We apply these methods to obtain quantitative results in a number of applications from emerging contaminants in water to metabolites in cell cultures.
Group members
Group managers
Anneli Kruve
Associate Professor
![Anneli Kruve](/polopoly_fs/1.473456.1576153018!/image/image.png_gen/derivatives/box_260/image.png)
Members
Yvonne Kreutzer
PhD student
![Yvonne Kreutzer](/polopoly_fs/1.668555.1692948415!/image/image.jpeg_gen/derivatives/box_260/image.jpeg)
Ida Rahu
Postdoktor
![](/webb2021/img/fallback_image_profile.png)
Anselm Irenäus Gordian Sandberg
PhD student
![](/webb2021/img/fallback_image_profile.png)
Henrik Hupatz
Postdoc
![](/webb2021/img/fallback_image_profile.png)
Wei-Chieh Wang
PhD Student
![Harry Wei-Chieh Wang](/polopoly_fs/1.622494.1660897768!/image/image.jpg_gen/derivatives/box_260/image.jpg)
Louise Malm
PhD Student
![Louise Malm](/polopoly_fs/1.622496.1660898078!/image/image.jpg_gen/derivatives/box_260/image.jpg)
Helen Sepman
PhD student
![Helen Sepman](/polopoly_fs/1.658726.1685513493!/image/image.jpg_gen/derivatives/box_260/image.jpg)
Amina Souihi
Doktorand
![Amina Souihi](/polopoly_fs/1.592400.1642511509!/image/image.jpg_gen/derivatives/box_260/image.jpg)
Drew Szabo
Postdoktor
![Drew Szabo](/polopoly_fs/1.601518.1646411677!/image/image.png_gen/derivatives/box_260/image.png)