Research group David Drew's research group
The Drew group investigates the alternating-access mechanism of solute transporters for sugars and ions. These transporters are critical to cell homeostasis and their dysfunction is associated with human diseases, such as cancer and diabetes.
Group description
Structure and mechanism of solute carrier transporters
Solute carrier transporters (SLCs) transporters are the targets for many therapeutics and they often play a major role in drug pharmacokinetics. Understanding the mechanisms by which SLC transporters shuttle and move ions, drugs, and natural compounds across membranes is of fundamental importance. Because of the technical difficulties in working with membrane proteins our mechanistic understanding is very limited. The goal of my research is to investigate the alternating-access mechanism of solute transporters for sugars and ions, which are critical to cell homeostasis and their dysfunction is associated with human diseases, such as cancer and diabetes. To achieve this we combine crystal and cryo EM structures with biochemical and biophysical techniques. These goals are facilitated by the development of novel methods to aid functional and structural investigation of SLC transporters.
Popular descriptions of our work on transporters
https://www.youtube.com/watch?v=fwW86e3tFv4
https://www.svd.se/genombrott-kan-leda-till-ny-malariamedicin
Group members
Group managers
David Drew
Professor of Biochemistry
Members
Dohwan Ahn
Researcher
Marta Bonaccorsi
Researcher
Magnus Claesson
Lab Manager
Ashutosh Gulati
Postdoc
Sukkyeong Jung
PhD student
Ved Mehta
Postdoc
Surabhi Rajendra Kokane
PhD student
Tom Reichenbach
Researcher
Albert Suades
Researcher
