Research project Asymmetric synthesis of boronic acids and organofluorine compounds by organocatalysis

Organoboron compounds are one of the most important class of reagents in organic synthesis in particular in synthesis of pharmaceuticals, new materials and complex natural products. Organoboron species excel in many areas of stereoselective synthesis involving catalytic cross-coupling reactions, allyl and propargylboration and synthesis of chiral allenes. The project aims to the development of new methods for asymmetric synthesis of organofluorine compounds with a boronic acid, B(OH)2, functionality. The applied catalytic homologation reaction is suitable for introduction of the B(OH)2 and fluorine containing groups to the same stereogen carbon. Subsequently, the B(OH)2 group can be replaced by other functional groups in high stereoselectivity, which opens new synthetic routes to chiral organofluorines.