SINFONIA is an EU-financed project on the development of a comprehensive system for personalised dosimetry in radiotherapy for patients treated for lymphoma and brain benign and malignant tumours.

The work done by our group in SINFONIA is part of an work package on novel patient dose estimation methods, risk assessment and uncertainty evaluation which includes the following tasks: the development of an innovative tool for the accurate estimation of organ doses from radiological examinations,, the development of a novel tool for the accurate estimation of organ doses from nuclear medicine examinations, the development of a comprehensive system for personalised dosimetry in radiotherapy and the appraisal of radiation-induced malignancies. Our particular aim is to development of a comprehensive system for personalised dosimetry in radiotherapy. Thus, a comprehensive methodology that includes measurement and simulation procedures will be developed to account for stray radiation dose in patients with lymphoma or/and brain tumours that receive radiation therapy with photon or proton beams. Personalised models of patients will be used with analytical algorithms to estimate dose distributions in out-of-field and partially exposed organs during photon radiation therapy. Treatment protocols applied in the clinic will be used together with machine-specific parameters to simulate dose delivery characteristics.
Measurements and Monte Carlo simulations will be used to estimate out-of-field and in-field dose distribution from stray radiation (neutrons) during proton therapy with the beam scanning technique. Organ-specific dose from stray radiation during radiotherapy exposures will be complemented by dose distributions from radiotherapy-related imaging procedures. A novel tool based on personalised dosimetry will be developed to determine 3D dose distributions within the patient and estimate of organ doses from imaging before, during and after radiation therapy.
uppskatta organdoser från avbildning före, under och efter strålbehandling.