Our group studies how bacteria grow and reproduce in fluctuating environments. We use a combination of genetics, cell biology and biochemistry to dissect the molecular mechanisms underlying bacterial growth and cell cycle progression and how these processes are regulated under changing environmental conditions to ensure bacterial survival.

Amino acids are essential nutrients that serve as building blocks of proteins and some are efficiently metabolized for energy. Eukaryotic cells respond to extracellular amino acids by enhancing their uptake. We study the molecular mechanisms underlying this response and the role of amino acid metabolism in promoting virulent growth of human fungal pathogens.

Our lab studies the functional role of chromatin changes and non-coding RNAs in gene regulation; in the regulation of ribosomal transcription in response to cellular states and in the regulation of the human immune response to pathogens.

As a new research group aiming to construct an international work environment with a mutual respect, our main objective is to enthusiastically investigate how a mammalian male germ cell commits to become a functional sperm. Our studies will therefore advance our understanding of sperm development and may suggest approaches to promote fertility.

Roger Karlsson's research reflects a long-standing interest in eukaryotic cell motility, i.e. movements of intracellular structures and migration of whole cells.

Our research aims at understanding the mechanisms by which RNA and RNA degradation by the exosome contribute to chromatin regulation, gene expression and genome integrity.

We are interested in biological and physical factors affecting cellular and molecular effects of ionising radiation. Focus is on DNA damage and repair, chromatin structure, low doses, low dose rates, mixed radiation qualities, fractionation and modulation by chemical and physical factors.